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A patient may have been losing weight consistently with semaglutide, tirzepatide, nutrition changes, increased activity, and medical follow-up—then suddenly the scale Sources Eli Lilly: Retatrutide showed positive Phase 3 topline results and remains investigational ClinicalTrials.gov: Retatrutide Phase 3 study record The Lancet Diabetes & Endocrinology: Effects of retatrutide on body composition in people with type 2 diabetes ScienceDirect: Retatrutide body-composition substudy summary The New England Journal of Medicine: Triple–Hormone-Receptor Agonist Retatrutide for Obesity — A Phase 2 Trial Nature Reviews Endocrinology: Balancing weight and muscle loss in GLP-1 receptor agonist therapy JAMA Internal Medicine: Integrating Diet and Physical Activity When Prescribing GLP-1s American Journal of Clinical Nutrition: Nutritional priorities to support GLP-1 therapy for obesity Acta Diabetologica: Muscle loss and GLP-1RA use